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    In Situ Investigations of the Formation of Mixed Supported Lipid Bilayers Close to the Phase Transition Temperature

    Year: 2004

    Journal: Nanoletters 2004, 4, No. 1 p. 5-10, 20100827

    Authors: Seantier B., Breffa C., Félix O., Decher G.

    Last authors: G. Decher

    Organizations: Centre National de la Recherche Scientifique (CNRS), Institut Charles Sadron, 6 rue Boussingault, F-67083 Strasbourg-Cedex, France, and Université Louis Pasteur (ULP), 1 rue Blaise Pascal, F-67008 Strasbourg-Cedex, France

    Country: France

    The formation of supported phospholipid bilayers (SPBs) has been studied by atomic force microscopy (AFM) and by dissipation-enhanced quartz crystal microbalance (QCM-D). AFM experiments on mixed bilayers of 1,2-dimyristoyl-sn-glycero-3-phosphatidylcholine (DMPC) and 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC) permit to visualize in situ the process of bilayer formation, starting with vesicle adsorption to the formation of bilayer patches and finally to complete bilayers. QCM-D experiments using the same systems show how the process and its kinetics are controlled by temperature.