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    In vivo biomechanical stability of osseointegrating mesoporous TiO2 implants

    Year: 2012

    Journal: Acta Biomaterialia, Volume 8, issue 12 (December, 2012), p. 4438-4446., 20130117

    Authors: Johan Karlsson a, Ryo Jimbo b, Hoda M. Fathali a, Humberto Osvaldo Schwartz-Filho b, Mariko Hayashi b, Mats Halvarsson c, Ann Wennerberg b, Martin Andersson a

    Last authors: Martin Andersson

    Organizations: a Department of Chemical and Biological Engineering, Applied Chemistry, Chalmers University of Technology, Gothenburg, Sweden b Department of Prosthodontics, Faculty of Odontology, Surface Biology Group, Malmö University, Malmö, Sweden c Department of Applied Physics, Microscopy and Microanalysis, Chalmers University of Technology, Gothenburg, Sweden

    Country: sweden, sverige

    Mesoporous materials are of high interest as implant coatings to receive an enhanced osseointegration. In this study, titanium implants coated with mesoporous TiO2 thin films have been evaluated both in vitro and in vivo. Material characterization showed that, with partly crystalline TiO2 (anatase), long-range-ordered hydrophilic mesoporous thin films with a pore size of 6 nm were obtained. Evaluation of the mechanical resistance showed that the films were robust enough to withstand the standard implantation procedure. In vitro apatite formation was studied using simulated body fluids, showing that the pores are accessible for ions and that formation of apatite was increased due to the presence of the mesopores. An in vivo study using a rabbit model was executed in which the removal torque and histomorphometry were evaluated. The results show that the biomechanical stability of the TiO2 coating was unaffected by the presence of mesopores and that osseointegration was achieved without any signs of inflammation.