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    Inherent antibacterial activity and in vitro biocompatibility of hydrophilic polymer film containing chemically anchored sulfadiazine moieties

    Year: 2017

    Journal: Eur. Polym. J., Volume 91, JUN, page 274–282

    Authors: Morro, Ana; Abrusci, Concepcion; Pablos, Jesus L.; Marin, Irma; Garcia, Felix C.; Garcia, Jose M.

    Organizations: Spanish Ministerio de Economia y Competitividad-Feder [MAT2014-54137-R, MAT2012-31709]; Consejeria de EducaciOn Junta de Castilla y Leon Feder [BUO61U16]

    Keywords: PVP; Sulfadiazine; Antibacterial polymer; Biocompatible

    Microbial colonisation of synthetic materials is a great concern in many fields, e.g., in implant surgery and medical devices; therefore biocompatible hydrophilic organic materials with inherent antimicrobial properties are of current research interest. In this work, we describe the preparation of antibacterial and biocompatible polymeric film based on N-vinyl-2-pyrrolidone (VP) and 2-hydroxyethyl acrylate (HEA), using ethyleneglycol dimethacrylate (EGDMA), and synthetic acrylic monomer containing sulfadiazine chemically anchored. The synthesised polyvinylpyrrolidone (PVP)-based films were characterized by different techniques (H-1 and C-13 NMR, ATR-FTIR, SEM, and TGA). In this study, the biophysical responses of bacteria and L929 cells towards the prepared materials as model device surfaces were evaluated. The membrane that contains the anchored sulfadiazine moiety showed excellent antibacterial activity against Escherichia coil as well as good biocompatibility. Based on the experimental results, this material is a good candidate for medical applications as a biomaterial.
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