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    Interaction of DNA Oligomers with Cationic Lipidic Monolayers: Complexation and Splitting

    Year: 2007

    Journal: Langmuir, 2007, 23 (8), pp 4414–4420, 20111221

    Authors: Svetlana Erokhina, Tatiana Berzina, Luigi Cristofolini, Oleg Konovalov, Victor Erokhin, and Marco P. Fontana

    Organizations: Department of Physics, University of Parma, Viale Usberti 7 A, 43100 Parma, Italy, Centro SOFT CNR-INFM, Rome, Italy, European Synchrotron Radiation Facility, 38043 Grenoble Cedex, France, and Institute of Crystallography, Russian Academy of Sciences, Leninsky pr. 59, Moscow, Russia

    Interactions of native DNA with octadecylamine (ODA) and hexadecymdimethylammonium bromide (HTAB) monolayers at the air/water interface were studied by π−A isotherms, ellipsometry, and X-ray reflectivity. We show that the microscopic structure of ODA−DNA complexes is definitely consistent with a single-stranded form for DNA. On the contrary, with HTAB, DNA complexes in its native form. The crucial difference in the behavior of these two fairly similar lipids is due to the presence of the amine group in ODA. These results should be relevant to applications such as DNA chips and sensors.