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    Interactions of amphotericin B with saturated and unsaturated

    Year: 2003

    Journal: Colloids and Surfaces B: Biointerfaces 29 (2003) 205-215, 20111221

    Authors: J. Miones, Jr , Patrycja Dynarowicztka , O. Conde , J. Miones , E. Iribarnegaray , M. Casas

    Organizations: a Department of Physical Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, 15706 Santiago de Compostela, Spain b Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Krakow, Poland

    Three synthetic phospholipids, differing in the degree of saturation of phosphatidylcholine (PC) acyl chains, namely: dipalmitoyl phosphatidylcholine (DPPC), dioleoyl phosphatidylcholine (DOPC) and palmitoyl-oleoyl phosphatidyl choline (POPC) were mixed with the antimycotic polyene antibiotic, amphotericin B (AmB), and investigated as monolayers at the air/water interface. The mixed films were spread on water (pH 6) at room temperature, and the surface pressure-area (π/A) isotherms were recorded upon compression. The interactions were examined by analysing the phase transitions of the monolayers and calculating the films compressibility. The obtained results indicate the existence of stronger interaction between AmB and the saturated phospholipid as compared with unsaturated ones, and reveal the influence of apolar structure of PC chains on the stoichiometry of AmB-PC complexes.