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    Layer-by-layer assembly of polymersomes and polyelectrolytes on planar surfaces and microsized colloidal particles

    Year: 2014

    Journal: J. Colloid Interface Sci, 2014, vol 421, p 132-140, 20140612

    Authors: Coustet, Marcos; Irigoyen, Joseba; Alonso Garcia, Teodoro; Murray, Richard A.; Romero, Gabriela; Susana Cortizo, M.; Knoll, Wolfgang; Azzaroni, Omar; Moya, Sergio E

    Last authors: Moya, Sergio E

    Organizations: [Coustet, Marcos; Susana Cortizo, M.; Azzaroni, Omar] UNLP, CONICET, Inst Invest Fis Quim Teor & Aplicadas INIFTA, Dept Quim,Fac Ciencias Exactas, RA-1900 La Plata, Buenos Aires, Argentina. [Irigoyen, Joseba; Alonso Garcia, Teodoro; Murray, Richard A.; Romero, Gabriela; Moya, Sergio E.] CIC BiomaGUNE, San Sebastian 20009, Spain. [Knoll, Wolfgang] AIT, A-1220 Vienna, Austria.

    Country: Argentina, Spain, Austria

    Hybrid polyelectrolyte multilayer systems were fabricated on top of planar surfaces and colloidal particles via layer by layer (LbL) assembly of polystyrene sulphonate (PSS) and polybenzyl methacrylateblock-poly(dimethylamino)ethyl methacrylate (PBzMA-b-PDMAEMA) polymersomes. Polymersomes were prepared by self assembly of PBzMA-b-PDMAEMA copolymer, synthesised by group transfer polymerisation. Polymersomes display a diameter of 270 nm and a shell thickness of 11 nm. Assembly on planar surfaces was followed by means of the Quartz Crystal Microbalance with Dissipation (QCM-D) and Atomic Force Microscopy (AFM). Detailed information on the assembly mechanism and surface topology of the polymersome/polyelectrolyte films was thereby obtained. The assembly of polymersomes and PSS on top of silica particles of 500 nm in diameter was confirmed by zeta-potential measurements. Confocal laser scanning microscopy (CLSM), scanning electron microscopy (SEM) and transmission electron microscopy (TEM) revealed that polymersome/PSS coated silica particles increase in total diameter up to 3-5 mu m. This hints toward the formation of densely packed polymersome layers. In addition, CLSM showed that polymersome/PSS films exhibit a high loading capacity that could potentially be used for encapsulation and delivery of diverse chemical species. These results provide an insight into the formation of multilayered films with compartmentalised hydrophilic/hydrophobic domains and may lead to the successful application of polymersomes in surface-engineered colloidal systems.