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    Liponucleoside thin films: The special behaviour of guanosine

    Year: 2013

    Journal: COLLOIDS AND SURFACES B-BIOINTERFACES, Vol. 103, p 45-51, 20150703

    Authors: Coga, Lucija; Ilc, Tina; Devetak, Miha; Masiero, Stefano; Gramigna, Lucia; Spada, Gian Piero; Drevensek-Olenik, Irena

    Organizations: Univ Ljubljana, Fac Math & Phys, SI-1000 Ljubljana, Slovenia; Jozef Stefan Inst, SI-1000 Ljubljana, Slovenia; Ctr Excellence Polymer Mat & Technol, SI-1000 Ljubljana, Slovenia; Alma Mater Studiorum Univ Bologna, Dipartimento Chim Organ A Mangini, I-40126 Bologna, Italy

    We performed a comparative study of self-assembling properties of liponucleoside materials containing different nucleobases in their hydrophilic headgroups, but possessing the same type of lipophilic moiety in their hydrophobic tails. Surface pressure versus area isotherms (pi(A)) of monolayers formed at the air-water interface show that guanine-based materials form stable monolayer films exhibiting a profound first order phase transition from the liquid expanded to the condensed phase. Materials based on other nucleobases form less stable films exhibiting a liquid-like behaviour. Analysis of surface structures of Langmuir films with Brewster angle microscopy (BAM) and of Langmuir-Blodgett (LB) films deposited on mica surface by atomic force microscopy (AFM) confirms surface organization as resolved from the isotherms. The specific behaviour of molecules with a guanine head group is attributed to their optimal hydrophilic/hydrophobic balance, which is associated with the low water solubility of guanine derivatives. (c) 2012 Elsevier B.V. All rights reserved.