Contact
    Start Publications Long-Lasting Antifouling Coating from Multi-Armed Polymer
    ←  Publication Finder
    QSense

    Long-Lasting Antifouling Coating from Multi-Armed Polymer

    Year: 2013

    Journal: Langmuir, 2013, 29 (32), pp 10087–10094, 20131001

    Authors: Boaz Mizrahi 1 3, Xiaojuan Khoo 1 3, Homer H. Chiang 1, Katalina J. Sher 3, Rose G. Feldman 3, Jung-Jae Lee 1 3, Silvia Irusta 2, and Daniel S. Kohane *1

    Last authors: Daniel S. Kohane

    Organizations: 1 Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Children’s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts 02115, United States 2 Institute of Nanoscience of Aragón, University of Zaragoza, Mariano Esquillor s/n, Zaragoza, 50018, Spain 3 Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States

    Country: USA, US, United States, United States of America, America, Spain

    We describe a new antifouling surface coating, based on aggregation of a short amphiphilic four-armed PEG-dopamine polymer into particles and on surface binding by catechol chemistry. An unbroken and smooth polymeric coating layer with an average thickness of approximately 4 μm was formed on top of titanium oxide surfaces by a single step reaction. Coatings conferred excellent resistance to protein adhesion. Cell attachment was completely prevented for at least eight weeks, although the membranes themselves did not appear to be intrinsically cytotoxic. When linear PEG or four-armed PEG of higher molecular weight were used, the resulting coatings were inferior in thickness and in preventing protein adhesion. This coating method has potential applicability for biomedical devices susceptible to fouling after implantation.