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    Nano-fiber scaffold electrodes based on PEDOT for cell stimulation

    Year: 2009

    Journal: Sensors and Actuators B: Chemical, Volume 142, Issue 2, 5 November 2009, Pages 451-456, 20111221

    Authors: Maria H. Bolin, Karl Svennersten, Xiangjun Wang, Ioannis S. Chronakis, Agneta Richter-Dahlfors, Edwin W.H. Jager and Magnus Berggren

    Organizations: Organic Electronics, Department of Science and Technology, Linköping University, SE-601 74 Norrköping, Sweden, Department of Neuroscience, Karolinska Institutet, SE-171 77 Stockholm, Sweden, Swerea IVF, Swedish Institute for Industrial Research & Development Corporation, Box 104, SE-431 22, Mölndal, Sweden, Experimental Solid State Group, Department of Physics, Imperial College London, SW7 2AZ London, UKStrategic Research Center for Organic Bioelectronics, Sweden

    Electronically conductive and electrochemically active 3D-scaffolds based on electrospun poly(ethylene terephthalate) (PET) nano-fibers are reported. Vapour phase polymerization was employed to achieve an uniform and conformal coating of poly(3,4-ethylenedioxythiophene) doped with tosylate (PEDOT:tosylate) on the nano-fibers. The PEDOT coatings had a large impact on the wettability, turning the hydrophobic PET fibers super-hydrophilic. SH-SY5Y neuroblastoma cells were grown on the PEDOT coated fibers. The SH-SY5Y cells adhered well and showed healthy morphology. These electrically active scaffolds were used to induce Ca2+ signalling in SH-SY5Y neuroblastoma cells. PEDOT:tosylate coated nano-fibers represent a class of 3D host environments that combines excellent adhesion and proliferation for neuronal cells with the possibility to regulate their signalling.