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    Nano/Microstructural Effect of Hydroxyapatite Nanocrystals on Hepatocyte Cell Aggregation and Adhesion

    Year: 2011

    Journal: Macromolecular Bioscience, Volume 11, Issue 11, pages 1586–1593, November 10, 2011, 20111207

    Authors: Tagaya M. 1 2*, Yamazaki T. 2, Tsuya D. 3, Sugimoto Y. 3, HanagataN 2, Ikoma T. 1 2

    Last authors: Toshiyuki Ikoma

    Organizations: 1 Department of Metallurgy and Ceramics Science, Graduate School of Science & Engineering, Tokyo Institute of Technology, O-okayama 2-12-1, Meguro-ku, Tokyo 152-8550, Japan 2 Biomaterials Center, National Institute for Materials Science, Sengen 1-2-1, Tsukuba, Ibaraki 305-0047, Japan 3 3-D Nano-Integration Foundry, National Institute for Materials Science, Sengen 1-2-1, Tsukuba, Ibaraki 305-0047, Japan

    Country: Japan

    Hepatocyte cell aggregation and adhesion to HAp nanocrystals covered with SU-8 polymer micropatterns by nano/microfabrication techniques is demonstrated. The surface roughness and wettability of the HAp nanocrystals are significantly different from those of the SU-8 polymer. QCM-D and microscopic observation clearly reveal that the cells realize the surface properties to form aggregation and preferentially adhere to the HAp nanocrystals at 2 h after seeding, indicating the importance of the microstructures as well as the interfacial phenomena at a nanometer scale.