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    Nanoencapsulation of Antitubercular Drug Isoniazid and Its Lipopeptide Conjugate

    Year: 2011

    Journal: Journal of Dispersion Science and Technology, 2011, 32 (12), 1728-1734, 20131009

    Authors: É. Kiss, D. Schnöller, K. Pribranská, K. Hill, Cs. B. Pénzes, K. Horváti, Sz. Bősze

    Organizations: Laboratory of Interfaces and Nanostructures, Eötvös Loránd University, Budapest, Hungary; Research Group of Peptide Chemistry, Eötvös Loránd University, Hungarian Academy of Sciences, Budapest, Hungary

    Isoniazid (INH) is a first line drug for treatment of the widespread deadly disease caused by Mycobacterium tuberculosis. Peptide conjugate of INH was designed and synthesised for targeted and receptor mediated cellular uptake of INH. Chemical composition, hydrophobicity (n-octanol/water partition coefficient), and membrane affinity (using a Langmuir lipid monolayer as a model system) of the conjugate were characterised. Hydrophilicity of the drug was remarkably decreased by the conjugation which resulted in improved interaction with lipid layer and allowed its efficient encapsulation into polylactic/glycolic acid nanoparticles enhancing the bioavailability of the drug.