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    Natural Polyelectrolyte Self-Assembled Multilayers Based on Collagen and Alginate: Stability and Cytocompatibility

    Year: 2013

    Journal: Biomacromolecules, 2013, 14 (8), pp 2647–2656, 20131002

    Authors: Wenxing Li 1, Peng Zhao 2, Chao Lin 2, Xuejun Wen 2 3, Eleni Katsanevakis 3, Decher Gero 4, Olivier Félix 4, and Yuehua Liu * 1

    Last authors: Yuehua Liu

    Organizations: 1 Department of Orthodontics, School of Stomatology, Tongji University, 399 YanChangZhong Road, Shanghai 200072, China 2 The Institute for Biomedical Engineering and Nanoscience, School of Medicine, Tongji University, 67 Chifeng Road, Shanghai 200092, China 3 Institute for Engineering and Medicine, Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, Virginia 23284-3028, United States 4 Institut Charles Sadron, Université de Strasbourg, UPR CNRS 22, F-67034 Strasbourg, France

    Country: USA, US, United States, United States of America, America, China, France

    Scientific interest in the self-assembly of collagen composite films has been increasing for their potential application in constructing bioactive materials. Here we report a highly stable and cytocompatible collagen/alginate (COL/ALG) ultrathin film, which was linearly fabricated via a layer-by-layer self-assembled technique. The variation in morphology and thickness of the films in air and in solutions with different pH and ion values were tested by atomic force microscopy. Results showed that the solutions with high pH values or solutions that contained electrolytes would disintegrate the film, while films with that were cross-linked for a long time prevented the dissolution and contributed to stability maintenance of the films. Interestingly, the COL/ALG coating not only improved the adhesion and proliferation of the human periodontal ligament cells, but also modified the morphology and migration of cells on the surface of glass and poly-l-lactic acid (PLA) electrospun scaffolds. In conclusion, the COL/ALG ultrathin films were highly stable and cytocompatible and could be easily fabricated by the cost-effective self-assembled technique presented. The findings of this study have the potential to play an important role in the surface modification of biomaterials.