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    Neuregulin 1 functionalization of organic fibers for Schwann cell guidance

    Year: 2017

    Journal: Nanotechnology, Volume 28, APR 18

    Authors: Tonazzini, Ilaria; Moffa, Maria; Pisignano, Dario; Cecchini, Marco

    Organizations: Italian Ministry of University and Research through the FIRB [RBNE08BNL7]; Network of Public Research Laboratories Wafitech; Fondazione Umberto Veronesi (Milano)

    Keywords: nanofiber; Schwann cells; neuregulin 1; nerve regeneration; contact guidance

    The repair of peripheral nerve lesions is a clinical problem where the functional recovery is often far from being satisfactory, although peripheral nerves generally retain good potential for regeneration. Here, we develop a novel scaffold approach based on bioactive fibers of poly(epsilon-caprolactone) where nanotopographical guidance and neuregulin 1 (NRG1) cues are combined. We interface them with rat primary Schwann cells (SCs), the peripheral glial cells that drive initial regeneration of injured nerves, and found that the combination of NRG1 with parallel nano-fibrous topographies is effective in improving SC growth up to 72 h, alignment to fiber topography, and bipolar differentiation, opening original perspectives for nerve repair applications.
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