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    Noncovalent Liposome Linkage and Miniaturization of Capsosomes for Drug Delivery

    Year: 2010

    Journal: Biomacromolecules, 2010, 11 (12), pp 3548–3555, 20110317

    Authors: Hosta-Rigau L. †‡, Chandrawati R. †‡, Saveriades E. ‡, Odermatt P.D. ‡, Postma A. §, Ercole F. §, Breheney K., Wark K.L., Städler B. ‡, Caruso F. *‡

    Last authors: Frank Caruso

    Organizations: ‡Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia, CSIRO, Molecular and Health Technologies, Clayton, Victoria 3168, Australia, CSIRO, Molecular and Health Technologies, Parkville, Victoria 3052, Australia, and Interdisciplinary Nanoscience Center, Aarhus University, Aarhus 8000, Denmark

    Country: Australia

    We report the synthesis of poly(methacrylic acid)-co-(oleyl methacrylate) with three different amounts of oleyl methacrylate and compare the ability of these polymers with that of poly(methacrylic acid)-co-(cholesteryl methacrylate) (PMAc) to noncovalently anchor liposomes to polymer layers. We subsequently assembled 1 μm diameter PMAc-based capsosomes, polymer hydrogel capsules that contain up to 2000 liposomal subcompartments, and investigate the potential of these carriers to deliver water-insoluble drugs by encapsulating two different antitumor compounds, thiocoraline or paclitaxel, into the liposomes. The viability of lung cancer cells is used to substantiate the cargo concentration-dependent activity of the capsosomes. These findings cover several crucial aspects for the application of capsosomes as potential drug delivery vehicles.