Year: 2013
Journal: Reactive & Functional Polymers, Volume 73, Issue 10, October 2013, Pages 1340–1348, 20131119
Authors: P.Basnett, K.Y.Ching, M.Stolz, J.C.Knowles, A.R.Boccaccini, C.Smith, I.C.Locke, T.Keshavarz, I.Roy
Organizations: Department ofApplied and Molecular Biosciences,School ofLife Sciences,University ofWestminster,115 New Cavendish Street,London W1W 6UW,UK, Department ofBiomedical Sciences,School ofLife Sciences,University ofWestminster,115 New Cavendish Street,London W1W 6UW,UK, National Centre for Advanced Tribology atSouthampton (nCATS),Engineering Sciences,Lanchester Building,Room 4077,University ofSouthampton,Southampton SO17 1BJ,UK, Division ofBiomaterials and Tissue Engineering,UCL Eastman Dental Institute,University College London,256 Gray’s Inn Road,London WC1X 8LD,UK, WCU Research Centre ofNanobiomedical Science,Dankook University,San#29,Anseo-dong,Dongnam-gu,Cheonan-si,Chungnam 330-714,South Korea, Department ofMaterials Science and Engineering,Institute ofBiomaterials,University ofErlangen-Nuremberg,91058 Erlangen,Germany
Novel Poly(3-hydroxybutyrate)/Poly(3-hydroxyoctanoate)blends were developed with varying amounts ofPoly(3-hydroxyoctanoate),P(3HO)and Poly(3-hydroxybutyrate),P(3HB)for their potential use invar- ious medical applications.These blend filmsexhib ited higher tensile strength and Young’s modulus val- ues comp ared toneat P(3HO).The overall protein adsorption and %cell viability was also found tobesignificantlyhigher inthe blend filmsthan the neat P(3HO)film.Hydrolytic degradation was faster inthe blend filmsand the degradation rate could potentially betailored toachieve the optimum rate required for aparticular medical application.Hence,these novel blends were found tobehighly biocom- patible with surface,mechanical and thermal properties suitable for arange ofpotential medical appli- cations,agreat step forward in the area ofmedical materials.
