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    Oxygen plasma modified P(3HB-4HB) used as anticoagulant materials

    Year: 2013

    Journal: Applied Surface Science Volume 280, 1 September 2013, Pages 564–571, 20131003

    Authors: Jiezhao Zhan 1 2 3, Xiaojun Tian 1 2 3, Yongjun Zhu 1 2 3, Lin Wang 1 2 3, Li Ren 1 2 3,

    Last authors: Li Ren

    Organizations: 1 School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China 2 National Engineering Research Center for Tissue Restoration and Reconstruction, Guangzhou 510006, China 3 Guangdong Province Key Laboratory of Biomedical Engineering, South China University of Technology, Guangzhou 510006, China

    Country: China

    In this article, we report the modification of P(3HB-4HB) film with oxygen plasma. The results showed that both the chemical components and topography of the P(3HB-4HB) film changed after oxygen plasma modification. In addition, the decrease of contact angle and the increase of the surface oxygen content were observed. The results of BSA adsorption onto those films studied by QCM-D showed that the plasma treatment could improve the protein-resistant activity of the film. After 10-minute plasma treatment, the BSA-resistant activity of the film improved 27% in PBS buffer solution and 57.5% in aqueous solution. Platelet adhesion test showed that the platelet-resistant activity of the film improved 68.6%, 82.3%, 96.8% after treated for 2, 5 and 10 min, respectively. Also, the cck8 assay of L929 cells showed that there was no cytotoxicity for the sample treated with oxygen plasma. This film has the potential to be used as anticoagulant materials, which required high protein-resistant activity.