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    Peptide-based stimuli-responsive biomaterials

    Year: 2006

    Journal: Soft Matter, 2006, 2, 822-835, 20120104

    Authors: Mart RJ 1, Osborne RD 2, Stevens MM 2 *, Ulijn RV 1 *

    Last authors: Rein V. Ulijn

    Organizations: 1 School of Materials and Manchester Interdisciplinary Biocentre (MIB), Grosvenor Street, Manchester, UK M1 7HS. E-mail: R.Ulijn@manchester.ac.uk; Fax: +44 161 3068877; Tel: +44 161 3065986 2 Department of Materials and Institute for Biomedical Engineering, Imperial College of Science, Technology and Medicine, Prince Consort Road, London, UK SW7 2AZ. E-mail: M.Stevens@imperial.ac.uk; Fax: +44 20 7594 6757; Tel: +44 20 7594 6804

    Country: England, UK, United Kingdom, GB, Great Britain, Britain, U.K.

    This article explores recent advances in the design and engineering of materials wholly or principally constructed from peptides. We focus on materials that are able to respond to changes in their environment (pH, ionic strength, temperature, light, oxidation/reduction state, presence of small molecules or the catalytic activity of enzymes) by altering their macromolecular structure. Such peptide-based responsive biomaterials have exciting prospects for a variety of biomedical and bionanotechnology applications in drug delivery, bio-sensing and regenerative medicine.