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    Poly (butylene/diethylene glycol succinate) multiblock copolyester as a candidate biomaterial for soft tissue engineering: Solid-state properties, degradability, and biocompatibility

    Year: 2012

    Journal: Journal of bioactive and compatible polymers 2012, 27 (3) 244-264, 20121211

    Authors: Chiara Gualandi, Michelina Soccio, Marco Govoni, Sabrina Valente, Nadia Lotti, Andrea Munari, Emanuele Giordano, Gianandrea Pasquinelli, Maria Letizia Focarete

    Organizations: Department of Chemistry “G Ciamician” and National Consortium of Materials Science and Technology (INSTM, RU Bologna), University of Bologna, Bologna, Italy , Advanced Applications in Mechanical Engineering and Materials Technology Interdepartmental Center for Industrial Research (CIRI MAM), University of Bologna, Bologna, Italy , Department of Civil, Environmental, and Materials Engineering (DICAM), University of Bologna, Bologna, Italy, Department of Biochemistry ‘G. Moruzzi’ Laboratory of Cellular and Molecular Engineering and National Institute for Cardiovascular Research, University of Bologna, Cesena, Italy, Anaestesiological and Surgical Sciences, University of Bologna, Bologna, Italy , Clinical Department of Radiological and Histocytomorphological Sciences, University of Bologna, Bologna, Italy

    A multiblock bioresorbable copolyester, poly(butylene/diethylene glycol succinate), was synthesized by reactive blending, and it was used, together with the corresponding poly(butylene succinate) homopolymer, to form films and to fabricate biomimetic electrospun scaffolds. The poly(butylene/diethylene glycol succinate) scaffold had a more pronounced elastomeric behavior than poly(butylene succinate). It also underwent hydrolytic degradation faster than poly(butylene succinate) since the incorporated diethylene glycol succinate units rendered the copolymer more hydrophilic than poly(butylene succinate). The films degraded faster than electrospun samples due to the autocatalytic effect of carboxylic end-groups. The biodegradable poly(butylene/diethylene glycol succinate) scaffold supported the growth and preserved the cardiac phenotype markers of H9c2 cells, demonstrating its potential utility in soft tissue engineering applications.