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    Poly (fumaroyl bioxirane) maleate: A potential functional scaffold for bone regeneration

    Year: 2017

    Journal: Mater. Sci. Eng. C-Mater. Biol. Appl., Volume 76, JUL 1, page 249–259

    Authors: Ding, Yi; Su, Yun; Lv, Ziyin; Sun, Hao; Bi, Xiaoping; Lu, Linna; Zhou, Huifang; You, Zhengwei; Wang, Yadong; Ruan, Jing; Gu, Ping; Fan, Xianqun

    Organizations: National High Technology Research and Development Program (863 Program) [2015AA020311]; National Natural Science Foundation of China [81320108010, 81570883, 81470662, 81500757, 81601623]; Shanghai Municipality Commission for Science and Technology [14JC1493103]; Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support [20161316]

    Keywords: Adipose-derived mesenchymal stem cells; Poly (fumaroyl bioxirane) maleate (PFM); Proliferation; Osteogenesis; Bone regeneration

    Proper scaffolds combined with mesenchymal stem cells (MSCs) represent a promising strategy for repairing bone defects. In a previous study, poly (fumaroyl bioxirane) maleate (PFM), a newly developed functional polymer with numerous functional groups, exhibited excellent biocompatibility and enhanced the alkaline phosphatase (ALP) activity of osteoblasts in vitro. Here, to provide further and comprehensive insight into the application of PFM in bone tissue engineering, we investigated the osteoinductive potential of PFM cultured with rat adipose derived mesenchymal stem cells (rADSCs). The results showed that PFM resulted in greater proliferation of rADSCs and that the PFM substrate had stronger osteoinductivity than PLGA and the control, as indicated by the significant upregulation of osteogenesis-related genes, proteins and calcium mineralization in vitro. Next, PFM was combined with rADSCs to repair a critical-sized calvarial defect in rats. Compared to the PLGA scaffold, the PFM scaffold significantly promoted new bone formation and exhibited excellent effects in repairing rat calvarial defects. In conclusion, PPM possesses strong osteoinductivity, which could markedly enhance bone regeneration, suggesting that PFM could serve as a promising and effective optimization method for traditional scaffolds in bone regeneration. (C) 2017 Elsevier B.V. All rights reserved.
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