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    Polyelectrolyte Coated PLGA Nanoparticles: Templation and Release Behavior

    Year: 2009

    Journal: Macromolecular Bioscience, 9 (4), April 8, 2009, Pages: 326-335, 20100827

    Authors: Zhou J 1 2, Moya S. 2 *, Ma L. 1, Gao C. 1 *, Shen J. 1

    Last authors: Jiacong Shen

    Organizations: 1Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China 2CIC BiomaGUNE, Paseo Miramón 182 Ed. Emp. C, San Sebastián, Spain

    Country: Spain

    Poly[(D,L-lactide)-co-glycolide] nanoparticles coated with polyethyleneimine on their surface were prepared by an emulsification-solvent evaporation method and subsequently surface modified by LBL assembly. The assembly of poly(acrylic acid) and polyethyleneimine on a planar substrate and on the PLGA nanoparticles was monitored by QCM-D, -potential, flow cytometry and TEM. Carboxylic and amino groups in the multilayers were crosslinked by carbodiimide condensation, which was also later used to graft poly(ethylene glycol) (PEG). Rhodamine 6G, 5(6)-carboxyfluorescein and fluorescein were incorporated into the nanoparticles and their release profiles were recorded at 60 °C and at 37 °C for rhodamine 6G, for nanoparticles with a multilayer coating, and those that were crosslinked and grafted with PEG.