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    Polyurethane Membranes Modified with Isopropyl Myristate as a Potential Candidate for Encapsulating Electronic Implants: A Study of Biocompatibility and Water Permeability

    Year: 2010

    Journal: Polymers 2010, 2(3), 102-119, 20111221

    Authors: Nima Roohpour 1, Jaroslaw M. Wasikiewicz 1 , Alireza Moshaverinia 1,2 , Deepen Paul 1 , Mike F. Grahn 3 , Ihtesham U. Rehman 1 and Pankaj Vadgama 1

    Organizations: 1. School of Engineering and Materials Science, Interdisciplinary Research Centre in Biomedical Materials, Queen Mary University of London, Mile End Road, London, E1 4NS, UK; E-Mails: wasikiewicz@yahoo.com (J.M.W.); moshaverinia.1@buckeyemail.osu.edu (A.M.); deepenpaul@yahoo.com (D.P.); iu.rehamn@qmul.ac.uk (I.U.R.); p.vadgama@qmul.ac.uk (P.V.) 2. Advanced Prosthodontics, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, CA, USA 3. Centre for Academic Surgery, Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, 4 Newark Street, London, E1 2AT, UK

    Medical polyurethanes have shown good bio-stability and mechanical properties and have been used as coating for implantable medical devices. However, despite their excellent properties, they are relatively permeable to liquid water and water vapour which is a drawback for electronic implant encapsulation. In this study polyether polyurethanes with different soft segment molecular weights were modified by incorporating isopropyl myristate (IPM), as a hydrophobic modifying agent, and the effect of IPM on water resistant and biocompatibility of membranes were investigated. IPM changed the surface properties of the polyurethane film and reduced its surface energy. Polyurethane films were found to be stable with IPM concentrations of 1–5 wt% based upon their chemistry; however it leached out in BSA at higher concentrations. Though, low concentrations of IPM reduced both liquid water and water vapour permeability; at higher IPM content liquid permeability did not improved significantly. In general, the polyurethane materials showed much lower water permeability compared with currently used silicone packaging material for electronic implants. In addition, cytotoxicity assessment of IPM containing polyurethanes showed no evidence of cytotoxcity up to 5 wt% IPM.