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    Preparation and properties of poly(epsilon-caprolactone)/bioactive glass nanofibre membranes for skin tissue engineering

    Year: 2018

    Journal: J. Bioact. Compat. Polym., Volume 33, MAR, page 195–209

    Authors: Lin, Zefeng; Gao, Wendong; Ma, Limin; Xia, Hong; Xie, Weihan; Zhang, Yu; Chen, Xiaofeng

    Organizations: Guangdong Key Laboratory of Orthopedic Technology and Implant Materials; Joint Funds of the National Natural Science Foundation of China [U1501245]; National Natural Science Foundation of China [51672088]; National Key Research and Development Program of China [2016YFB0700800]; Scientific and Technological Projects of Guangdong Province, China [2015B010106005]; Scientific and Technological Projects of Guangzhou, China [201604020110]

    Keywords: Bioactive glass; poly(epsilon-caprolactone); nanofibres; mechanical properties; skin tissue engineering

    Poly(epsilon-caprolactone) composite nanofibres for skin tissue engineering and regeneration applications were prepared via electrospinning of poly(epsilon-caprolactone) nanofibres with bioactive glass nanoparticles at bioactive glass contents of 0, 2, 4, 6 and 8wt%. The surface properties, water absorptivities, porosities, mechanical properties and biocompatibilities of the composite electrospun nanofibres were characterised in detail. Addition of bioactive glass improved the hydrophilicity and elastic modulus of membranes. The fibre diameter of the neat poly(epsilon-caprolactone) nanofibres was only 700nm, but reinforcement with 2, 4, 6 and 8wt% bioactive glass nanofibres increased the diameter to 1000, 1100, 900 and 800nm, respectively. The minimum elongation at break of the bioactive glass-reinforced poly(epsilon-caprolactone) exceeded 100%, which indicated that the composite nanofibres had good mechanical properties. The porosities of the various nanofibres containing different mass loadings of bioactive glass all exceeded 90%. The best performance in terms of cell proliferation and adhesion was found when the bioactive glass mass percent reached 6wt%. However, higher loadings were unfavourable for cell growth. These preliminary results indicate that poly(epsilon-caprolactone)/bioactive glass composite nanofibres have promise for skin tissue engineering applications.
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