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    Protein resistant properties of polymers with different branched architecture on a gold surface

    Year: 2012

    Journal: J. Mater. Chem., 2012,22, 23852-23860, 20130118

    Authors: Yuanyuan Zhuang a, Qi Zhu *a, Chunlai Tu a, Dali Wang a, Jieli Wu b, Yumin Xia c, Gangsheng Tong b, Lin He *b, Bangshang Zhu b, Deyue Yan, a Xinyuan Zhu *ab

    Last authors: Xinyuan Zhu

    Organizations: aSchool of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. China. E-mail: xyzhu@sjtu.edu.cn; firstzq@ sjtu.edu.cn; Fax: +86-21-34205722; Tel: +86-21-34205699 bInstrumental Analysis Center, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. China. E-mail: xyzhu@sjtu. edu.cn cCollege of Materials Science and Engineering, Donghua University, 2999 North Renmin Road, Shanghai 201620, P. R. China

    Country: China

    To elucidate the effect of polymeric branched architecture on the protein resistant properties, the protein adsorption behaviour of polymers with different branched architectures on a gold surface was investigated. A series of poly((S-(4-vinyl) benzyl S′-propyltrithiocarbonate)-co-(poly(ethylene glycol) methacrylate))s (poly(VBPT-co-PEGMA)s) with different branched architecture were prepared by reversible addition-fragmentation chain transfer (RAFT) copolymerization, and then grafted onto a gold surface via thiols obtained from aminolysis reaction. With the increase of polymeric branched architecture, the thiol content of poly(VBPT-co-PEGMA)s increased, resulting in the formation of a highly uniform film with high stability and multifunctionality on the gold substrate. On the other hand, incubation of the poly(VBPT-co-PEGMA)-coated surface with bovine serum albumin (BSA) and immunoglobulin (IgG) showed that the protein resistant properties of the polymer-coated surface were enhanced with the decrease of branched architecture. After surface coating with branched poly(VBPT-co-PEGMA) onto a gold surface, the adhesion and proliferation of Hela cells were inhibited efficiently. By only adjusting the branched architecture of polymers on a substrate, the high protein resistance and multifunctionality can be integrated together, realizing the optimization of nonfouling properties of polymer-coated surface.