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    Regenerated cellulose micro-nano fiber matrices for transdermal drug release

    Year: 2017

    Journal: Mater. Sci. Eng. C-Mater. Biol. Appl., Volume 74, MAY 1, page 485–492

    Authors: Liu, Yue; Nguyen, Andrew; Allen, Alicia; Zoldan, Janet; Huang, Yuxiang; Chen, Jonathan Y.

    Organizations: American Association of Textile Chemists and Colorists Foundation [UTA15-00082]; China Scholarship Council

    Keywords: Cellulose; Ionic liquid; Microfiber; Nanofiber; Electrospinning; Drug delivery

    In this work, biobased fibrous membranes with micro-and nano-fibers are fabricated for use as drug delivery carries because of their biocompatibility, eco-friendly approach, and potential for scale-up. The cellulose micro-/nano-fiber (CMF) matrices were prepared by electrospinning of pulp in an ionic liquid, 1-butyI-3-methylimidazolium chloride. A model drug, ibuprofen (IBU), was loaded on the CMF matrices by a simple immersing method. The amount of IBU loading was about 6% based on the weight of cellulose membrane. The IBU-loaded CMF matrices were characterized by Fourier-transform infrared spectroscopy, thermal gravimetric analysis, and scanning electron microscopy. The test of ibuprofen release was carried out in an acetate buffer solution of pH 5.5 and examined by UV-Vis spectroscopy. Release profiles from the CMF matrices indicated that the drug release rate could be determined by a Fickian diffusion mechanism. (C) 2016 Elsevier B.V. All rights reserved.
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