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    Reinforced Degradable Biocomposite by Homogenously Distributed Functionalized Nanodiamond Particles

    Year: 2015

    Journal: MACROMOLECULAR MATERIALS AND ENGINEERING, Vol. 300, p 436-447, 20170208

    Authors: Sun, Yang; Finne-Wistrand, Anna; Waag, Thilo; Xing, Zhe; Yassin, Mohamed; Yamamoto, Akihito; Mustafa, Kamal; Steinmueller-Nethl, Doris; Krueger, Anke; Albertsson, Ann-Christine

    Organizations: Royal Inst Technol, KTH, Sch Chem Sci & Engn, Fibre & Polymer Technol, S-10044 Stockholm, Sweden; Univ Wurzburg, Inst Organ Chem, D-97074 Wurzburg, Germany; Univ Bergen, Ctr Clin Dent Res, Dept Clin Dent, N-5009 Bergen, Norway; Nagoya Univ, Grad Sch Med, Dept Oral & Maxillofacial Surg, Showa Ku, Nagoya, Aichi 4668550, Japan; DiaCoating GmbH, A-6020 Innsbruck, Austria

    Severe phase separation was observed in blending nanodiamond particle (n-DP) in poly (L-lactide-co-e-caprolactone) (poly(LLA-co-CL)) scaffold. In this study we optimized the scaffold by the addition of 1-50% (w/w) polylactide modified n-DP (n-DP-PLA) or benzoquinone-modified n-DP (n-DP-BQ). Composed by 10% n-DP-PLA, composite had 6 times higher E-modulus in tensile test, whereas the maximum reinforcement can be higher than 15 times. However, n-DP-BQ composites conserved the mechanical properties, and thermal properties of the polymer substrate. The attachment, spreading and growth of UE7T13 cells on modified n-DP composites were similar to poly(LLA-co-CL), and independent to n-DP concentrations. In summary, a proper modified n-DP is the key to reinforce poly(LLA-co-CL) for tissue engineering.