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    Relaxation dynamics in ultrathin polymer films

    Year: 1998

    Journal: Physical Review E, August 1998, Vol 58 nr 2, p R1226-R1229, 20100827

    Authors: Forrest J. A. 1, Svanberg C. 1, Révész K. 2, Rodahl M. 2, Torell L. M. 1, Kasemo B. 2

    Last authors: B. Kasemo

    Organizations: 1Department of Experimental Physics, Chalmers University of Technology, S-412 96 Göteborg, Sweden 2Department of Applied Physics, Chalmers University of Technology, S-412 96 Göteborg, Sweden

    Country: Sweden

    A method based on the piezoelectric Quartz Crystal Microbalance (QCM) technique for in vitro real-time characterization of cell attachment and spreading on surfaces has been endeavored. The method simultaneously measures the resonant frequency (f) and the dissipation energy (D) of the oscillating system. The QCM-Dâ„¢ responses are sensitive to very small amounts (a few hundreds) of cells and highly specific to surface chemical properties. In this contribution, we present our first results from deposition of cells on two polystyrene surfaces of different wettability in serum-containing medium. It has previously been shown that a decrease in f is related to the degree of cell spreading. In our data it appears that the extent or quality of cell attachment is reflected in an increase in D caused by adhering cells. The combined information from f and D measured by this technique might therefore be useful to probe cell-surface interactions for biomaterials.