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    Response of human alveolar bone-derived cells to a novel poly(vinylidene fluoride-trifluoroethylene)/barium titanate membrane

    Year: 2011

    Journal: Journal of materials science. Materials in medicine, Volume 22, Number 1, 151-158, 20111221

    Authors: L. N. Teixeira, a, G. E. Crippa, b, R. Gimenes, c, M. A. Zaghete, c, P. T. de Oliveira, a, A. L. Rosa, b, M. M. Beloti, a

    Organizations: a Department of Morphology, Stomatology and Physiology, School of Dentistry of Ribeirao Preto, University of Sao Paulo, Av. do Cafe, s/n, Ribeirao Preto, SP 14040-904, Brazil, b Department of Oral and Maxillofacial Surgery and Periodontology, School of Dentistry of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil, b CMDC, Chemistry Institute of Araraquara, Sao Paulo State University, Sao Paulo, SP, Brazil, c CMDC, Chemistry Institute of Araraquara, Sao Paulo State University, Sao Paulo, SP, Brazil

    A new deposition method is presented, based on electrospraying, that can build bioceramic structures
    with desirable surface properties. This technology allows nanoapatite crystals, including hydroxyapatite
    (nHA), carbonate-substituted HA (nCHA) and silicon-substituted HA (nSiHA), to be electrosprayed on
    glass substrates. Human osteoblast cells cultured on nSiHA showed enhanced cell attachment, proliferation and protein expression, namely alkaline phosphatase, type 1 collagen and osteocalcin, as compared
    to nHA and nCHA. The modification of nanoapatite by the addition of silicon into the HA lattice structure
    renders the electrosprayed surface more hydrophilic and electronegatively charged.