Contact
    Start Publications Semi-Synthetic Polysaccharide Sulfates as Anticoagulant ...
    ←  Publication Finder
    QSense

    Semi-Synthetic Polysaccharide Sulfates as Anticoagulant Coatings for PET, 1 – Cellulose Sulfate

    Year: 2011

    Journal: Macromolecular Bioscience, Volume 11, Issue 4, pages 549–556, April 8, 2011, 20110525

    Authors: Gericke M. 1, Doliška A. 2, Stana J. 3, Liebert T. 1, Heinze T. 1*, Stana-Kleinschek K. 2,*

    Last authors: Karin Stana-Kleinschek

    Organizations: 1 Institute of Organic Chemistry and Macromolecular Chemistry, Friedrich Schiller University of Jena, Centre of Excellence for Polysaccharide Research, Humboldtstraße 10, D-07743 Jena, Germany 2 Laboratory for Characterization and Processing of Polymers, Faculty of Mechanical Engineering, University of Maribor, Smetanova 17, SI-2000 Maribor, Slovenia 3 Faculty of Medicine, University of Maribor, Smetanova 17, SI-2000 Maribor, Slovenia

    Country: Germany, Slovenia

    In the present study, blood-compatible PET surfaces were prepared by coating with anticoagulant cellulose sulfates that were synthesized homogeneously in ionic liquids. The adsorption behavior of polysaccharides on PET films was investigated using QCM-D. It was demonstrated that pre-coating with different amino-group-containing polysaccharides improves the affinity toward cellulose sulfate. Moreover, the effect of different degrees of sulfation on the adsorption process was evaluated. Based on these results, several layer-by-layer coated PET foils were prepared that showed significantly improved blood compatibility compared to the initial untreated material.