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    Solvent effects on amphotericin B monolayers

    Year: 2004

    Journal: Journal of Colloid and Interface Science 269 (2004) 499-502, 20111221

    Authors: Jennifer Cannon Sykora, William C. Neely, and Vitaly Vodyanoy

    Organizations: a Department of Chemistry, Auburn University, Auburn, AL 36849, USA b Department of Anatomy, Physiology and Pharmacology, Auburn University, Auburn, AL 36849, USA

    Monolayers of the antifungal antibiotic amphotericin B undergo the liquid expanded/liquid condensed state transition if spread from chloroform/methanol solvent. The transition disappeared after a long spreading time. The presence of the transition may be due to the retention of solvent and/or the presence of metastable aggregates of amphotericin B.