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    Spontaneous Formation of a Vesicle Multilayer on Top of an Exponentially Growing Polyelectrolyte Multilayer Mediated by Diffusing Poly-L-lysine

    Year: 2011

    Journal: J. Phys. Chem. B, 2011, 115 (43), pp 12386–12391, 20111207

    Authors: Graf N., Thomasson E., Tanno A., Vörös J., Zambelli T.*

    Last authors: Tomaso Zambelli

    Organizations: Laboratory of Biosensors and Bioelectronics, Institute for Biomedical Engineering, ETH Zürich, Gloriastrasse 35, 8092 Zürich, Switzerland

    Country: Switzerland

    We observed the spontaneous formation of vesicle-multilayers on top of a polyelectrolyte multilayer (PEM). By varying the thickness of underlying PEM (uPEM) it was possible to tailor the amount of adsorbing liposomes. Thereby, the loading capacity could be increased up to 17 times with respect to a monolayer of vesicles for an uPEM of 50.5 bilayers. We, furthermore, proved that the formation of the vesicle multilayer is due to the ability of poly-l-lysine to diffuse within the uPEM. This method could be interesting for applications in sensors and drug delivery systems where the increase in loading capacity is highly desired.