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    Study of penetration of amphotericin B into cholesterol or ergosterol containing dipalmitoyl phosphatidylcholine Langmuir monolayers

    Year: 2003

    Journal: Colloids and Surfaces B: Biointerfaces 27 (2002) 249-263, 20111221

    Authors: P. Dynarowicztka , R. Seoane , J. Minones, Jr , M. Velo , J. Minones

    Organizations: a Department of General Chemistry, Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Cracow, Poland b Department of Physical Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, Campus Sur, 15706 Santiago de Compostela, Spain

    The interactions of amphotericin B (AmB) with sterols and phospholipids have been studied by adsorption of AmB from aqueous solutions into Langmuir monolayers from dipalmitoyl phosphatidylcholine (DPPC), ergosterol, cholesterol and their mixtures. The results show that AmB exhibits stronger interaction with cholesterol than ergosterol in one-component monolayers. However, for DPPC-/sterol monolayers, the effectiveness of AmB penetration depends on the proportion of both film components in the mixed film as well as on the strength of interaction between DPPC and particular sterol.