Contact
    Start Publications Study on glucose release ability from hydroxypropyl cellulose ...
    ←  Publication Finder
    Attension

    Study on glucose release ability from hydroxypropyl cellulose films

    Year: 2015

    Journal: POLYMER BULLETIN, Vol. 72, p 549-563, 20170208

    Authors: Nechifor, Cristina-Delia; Barzic, Andreea Irina; Stoica, Iuliana; Closca, Valentina; Dorohoi, Dana-Ortansa

    Organizations: Gheorghe Asachi Tech Univ Iasi, Fac Machine Mfg & Ind Management, Dept Phys, Iasi 700050, Romania; Petru Poni Inst Macromol Chem, Iasi 700487, Romania; Alexandru Ioan Cuza Univ, Fac Phys, Iasi 700506, Romania

    Drug delivery systems based on different glucose and hydroxypropyl cellulose (HPC) ratios were prepared and characterized to check their suitability as controlled drug delivery carriers. The surface polarity and topography were analyzed and correlated with the glucose/HPC ratio and the drug release mechanism. Different mathematical models were used to fit the 'in vitro' release data to understand the glucose release mechanism. The in vitro release data analyzed using various kinetic models showed that all the samples were governed by first-order kinetics; however, one sample seems to have a behavior closer to zero-order kinetics. When a higher percentage HPC was added, the release process was described by Fickian diffusion. An anomalous diffusion was correlated with a lower HPC content. The study showed that glucose/HPC is an interesting matrix for the preparation of controlled release systems which can provide a constant glucose dose over a 4-h period.