Contact
    Start Publications Superhydrophobic nitric oxide-releasing xerogels
    ←  Publication Finder
    Attension

    Superhydrophobic nitric oxide-releasing xerogels

    Year: 2014

    Journal: ACTA BIOMATERIALIA, Vol. 10, p 3442-3448, 20150722

    Authors: Storm, Wesley L.; Youn, Jonghae; Reighard, Katelyn P.; Worley, Brittany V.; Lodaya, Hetali M.; Shin, Jae Ho; Schoenfisch, Mark H.

    Organizations: Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA; Kwangwoon Univ, Dept Chem, Seoul 139701, South Korea

    Superhydrophobic nitric oxide (NO)-releasing xerogels were prepared by spray-coating a fluorinated silane/silica composite onto N-diazeniumdiolate NO donor-modified xerogels. The thickness of the superhydrophobic layer was used to extend NO release durations from 59 to 105 h. The resulting xerogels were stable, maintaining superhydrophobicity for up to 1 month (the longest duration tested) when immersed in solution, with no leaching of silica or undesirable fragmentation detected. The combination of superhydrophobicity and NO release reduced viable Pseudomonas aeruginosa adhesion by >2-logs. The killing effect of NO was demonstrated at longer bacterial contact times, with superhydrophobic NO-releasing xerogels resulting in 3.8-log reductions in adhered viable bacteria vs. controls. With no observed toxicity to L929 murine fibroblasts, NO-releasing superhydrophobic membranes may be valuable antibacterial coatings for implants as they both reduce adhesion and kill bacteria that do adhere. (C) 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.