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    Surface adsorption of fibronectin-derived peptide fragments: the influence of electrostatics and hydrophobicity for endothelial cells adhesion

    Year: 2012

    Journal: Soft Matter, 2012, 8, 53-56, 20111207

    Authors: Satriano C. *1, Fragalà M.E 1, Forte G 2, Santoro A.M. 3, La Mendola D. 3, Kasemo B. 4

    Last authors: Bengt Kasemo

    Organizations: a Department of Chemical Sciences and INSTM, Catania University, viale Andrea Doria, 6, 95125, Catania, Italy. E- b Department of Pharmaceutical Sciences, Catania University, viale Andrea Doria, 6, 95125, Catania, Italy c Institute of Biostructures and Bioimages, CNR-Catania, viale Andrea Doria, 6, 95125, Catania, Italy d Department of Applied Physics, Chalmers University of Technology, Gothenburg, Sweden

    Country: Italy, Sweden, Sverige

    The adsorption on hydrophobic and hydrophilic silica-based surfaces of the integrin-binding PHSRN peptide and the single-residual-mutated analogues, PHSEN and PHSFN, is investigated by comparative QCM-D, XPS, SFG measurements and molecular dynamics calculations. Endothelial cell cultures on the peptide-functionalized materials highlight their tunable pro- or anti-angiogenic potential.