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    Surface Modification with Alginate-Derived Polymers for Stable, Protein-Repellent, Long-Circulating Gold Nanoparticles

    Year: 2012

    Journal: ACS Nano, 2012, 6 (6), pp 4796–4805, 20120922

    Authors: Anu Kodiyan †‡, Eduardo A. Silva †§, Jaeyun Kim †// , Michael Aizenberg †, and David J. Mooney † *

    Last authors: David J. Mooney

    Organizations: † Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, Massachusetts 02138, United States ‡ École Polytechinique Fédérale de Lausanne, 1015 Lausanne, Switzerland § Department of Biomedical Engineering, University of California, Davis, California 95616, United States School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, United States //School of Chemical Engineering, Sungkyunkwan University, Suwon 440-746, Korea

    Country: Switzerland, Korea, USA, US, United States, United States of America, America

    Poly(ethylene) glycol is commonly used to stabilize gold nanoparticles (GNPs). In this study, we evaluated the ability of cysteine-functionalized alginate-derived polymers to both provide colloidal stability to GNPs and avoid recognition and sequestration by the body’s defense system. These polymers contain multiple reactive chemical groups (hydroxyl and carboxyl groups) that could allow for ready functionalization with, for example, cell-targeting ligands and therapeutic drugs. We report here that alginate-coupled GNPs demonstrate enhanced stability in comparison with bare citrate-coated GNPs and a similar lack of interaction with proteins in vitro and long in vivo circulation as PEG-coated GNPs. Keywords: G-block; PEG; protein repellence; thiol polymers; cellular uptake; pharmacokinetics