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    Surfactant-dependent macrophage response to polypyrrole-based coatings electrodeposited on Ti6Al7Nb alloy

    Year: 2013

    Journal: Materials Science and Engineering, C, 33, pp 3353-3361, 20130926

    Authors: Mihaela Mindroiu, Raluca Ion, Cristian Pirvu, Anisoara Cimpean

    Organizations: University Polytechnica of Bucharest, Faculty of Applied Chemistry and Materials Science, 1-7 Polizu, 011061, Bucharest, Romania, University of Bucharest, Department of Biochemistry and Molecular Biology, 91-95 Spl. Independentei, 050095, Bucharest, Romania

    In this study, polypyrrole (PPy) films were successfully synthesized on Ti6Al7Nb alloy by potentiostatic polymerizationin the presence of poly(sodium 4-styrenesulfonate) (NaPSS), t-octylphenoxy polyethoxyethanol(Triton X-100) and N-dodecyl-β-D-maltoside (DM) surfactants. Atomic force microscopy (AFM) analysis ofthe PPy/surfactant composite films revealed a granular structure characterized by a lower surface roughnessthan un-modified PPy films. The results demonstrated that addition of surfactants, namely Triton X-100 andDM, can improve electrochemical film stability and corrosion resistance. Further, Triton X-100 enhanced theadhesive strength of PPy films to the substrate. The surfactant type also showed a great influence on the surfacewettability, the highest hydrophilic character being observed in the case of PPy/PSS film. Few studies have beendevoted to the elucidation of inflammatory cell response to PPy-based materials. Therefore, RAW264.7 macrophageswere cultured on PPy-surfactant films to determine whether they elicit a differential cell behavior interms of cell adhesion, proliferation, cellular morphology and cytokine secretion. Our results highlight thedependence of macrophage response on the surfactants used in the pyrrole polymerization process and suggestthat the immune response to biomaterials coated with PPy films might be controlled by the choice of surfactantmolecules.