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    Synthesis and biocompatibility of anionic polyurethane nanoparticles coated with adsorbed chitosan

    Year: 2010

    Journal: Polymer, Volume 51, Issue 9, 20 April 2010, Pages 1926-1933, 20111221

    Authors: Dan Xu a,b,c , Ke Wu d , Qiuhong Zhang b,c , Heyi Hu b , Kai Xi b , Qingming Chen a,b , Xuehai Yu b , Jiangning Chen d, Xudong Jia a,b,c

    Organizations: a State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093, P. R. China, b Department of Polymer Science and Engineering, Nanjing University, Nanjing 210093, P. R. China, c Nanjing National Laboratory of Microstructures, Nanjing University, Nanjing 210093, P. R. China, d State Key Laboratory of Pharmaceutical Biotechnology, Department of Biochemistry, Nanjing University, Nanjing 210093, P.R. China

    Through the assembly of polyelectrolyte in aqueous emulsion, we synthesized a series of core–shell ionic complex nanoparticles containing anionic polyurethane (PU) and cationic chitosan (CS). The physicochemical properties of PU–CS ionic complex (PU-c-CS) materials were investigated by IR, XPS, DLS, TEM, AFM, general tensile tests, and surface contact angle measurement. It was found that the sizes of the prepared nanoparticles were in the range from 60 to 220 nm, and the films exhibited good mechanical properties. The cell (HUVECs) culture experiments showed that the PU-c-CS films exhibited very low cytotoxicity and supported cell adhesion and growth. Protein (BSA) adsorption was significantly decreased for the PU-c-CS films. Furthermore, the results of prothrombin time (PT) and activated partial thromboplastin time (APTT) indicated that antithrombogenicity of the materials were effectively improved.