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    Synthesis of elastic biodegradable polyesters of ethylene glycol and butylene glycol from sebacic acid

    Year: 2012

    Journal: Acta Biomaterialia 2012, 8, (8), pp 2911-2918, 20121211

    Authors: Hyung-seok Park, Jung-a Seo, Hye-Young Lee, Hae-Won Kim, Ivan B. Wall, Myoung-Seon Gong and Jonathan C. Knowles

    Organizations: Department of Nanobiomedical Science & WCU Research Center, Dankook University Graduate School, Cheonan 330-714, South Korea; Division of Biomaterials and Tissue Engineering, UCL Eastman Dental Institute, 256 Gray’s Inn Road, London WC1X 8LD, UK; Department of Biochemical Engineering, University College London, Torrington Place, London WC1E 7JE, UK; Institute of Tissue Regeneration Engineering, Dankook University, Cheonan 330-714, South Korea

    High molecular weight biodegradablepolyesters were prepared from sebacicacid, ethyleneglycol and butyleneglycol through a simple non-solvent polycondensation with a low toxicity catalyst. The successful synthesis of the polyesters was confirmed by gel permeation chromatography, 1H-nuclear magnetic resonance and Fourier transform-infrared spectroscopies and differential scanning calorimetry. The degradation tests were performed at 37 °C in phosphate buffer solution (pH 7.4) and showed a mass loss of ~5% over 12 weeks compared with only 2% for polycaprolactone (PCL). Reverse transcription polymerase chain reaction results following culture of osteoblasts on the polymer surface showed that poly(ethylene sebacate) and poly(butylene sebacate) films were optimal for osteoblast formation in terms of Runx 2 and osteocalcin gene expression.