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    Synthesis of oligo(lactose)-based thiols and their self-assembly onto gold surfaces

    Year: 2013

    Journal: Colloids and Surfaces B Biointerfaces, 2013, 105, pp 187-193, 20130926

    Authors: Timmy Fyrner, Thomas Ederth, Daniel Aili, Bo Liedberg, Peter Konradsson

    Organizations: Division of Chemistry, IFM, Linköping University, SE-581 83 Linköping, Sweden; Division of Molecular Physics, IFM, Linköping University, SE-581 83 Linköping, Sweden; School of Materials Science and Engineering, Nanyang Technological University, 639798 Singapore, Singapore

    The ability to produce monomolecular coatings with well-defined structural and functional properties is of key importance in biosensing, drug delivery, and many recently developed applications of nanotechnology. Organic chemistry has proven to be a powerful tool to achieve this in many research areas. Herein, we present the synthesis of three oligo(lactosides) glycosylated in a (1 → 3) manner, and which are further functionalized with amide-linked short alkanethiol spacers. The oligosaccharides (di-, tetra-, and hexasaccharide) originate from the inexpensive and readily available lactose disaccharide. These thiolated derivatives were immobilized onto gold surfaces, and the thus formed self-assembled monolayers (SAMs) on planar gold were characterized by wettability, ellipsometry and infrared reflection–absorption spectroscopy. Further, the ability of these SAMs to stabilize gold nanoparticles in saline solutions was also demonstrated, indicating that the oligosaccharides may be used as stabilizing agents in gold nanoparticle-based assays.