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    Synthesis of star polymer poly(ethylene glycol)3–poly(N,N-dimethyl acrylamide) and its application in protein resistance and separation

    Year: 2013

    Journal: Journal of Applied Polymer Science Volume 129, Issue 3, pages 1179–1186, 5 August 2013, 20130630

    Authors: Jinxing Xing, Lin Tan, Fuhu Cao, Yanmei Wang*

    Last authors: Yanmei Wang

    Organizations: Chinese Academy of Sciences, Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei 230026, People's Republic of China Email: Yanmei Wang (wang@ustc.edu.cn) *Chinese Academy of Sciences, Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei 230026, People's Republic of China

    Country: China

    A star polymer composed of three poly(ethylene glycol) (PEG) arms and one poly(N,N-dimethyl acrylamide) (PDMA) arm (PEG3–PDMA) was synthesized by amidation and atom-transfer radical polymerization. The structure of PEG3–PDMA was confirmed by 1H-NMR and gel permeation chromatography results. The surface adsorption and protein-resistance behaviors of the star polymer PEG3–PDMA, diblock copolymer PEG–PDMA, and homopolymer PEG were investigated by a quartz crystal microbalance with dissipation. The results indicate that the PEG3–PDMA coating could reduce protein adsorption to 13% at least, more effectively than the PEG–PDMA coating; this indicated that the protein-resistance properties depended on the PEG chain density and surface coverage. If PEG3–PDMA were to be used as the physical coating in capillary zone electrophoresis, it could yield a well-suppressed eletroosmotic flow with greater stability and separate proteins with a lower relative standard deviration (RSD) of protein migration time and a higher separation efficiency than a bare fused-silica capillary in a broad pH range. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013