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    Tailoring controlled-release oral dosage forms by combining inkjet and flexographic printing techniques

    Year: 2012

    Journal: European journal of pharmaceutical science, 2012, 47 (3) pp 615-623, 20130115

    Authors: Natalja Genina, Daniela Fors, Hossein Vakili, Petri Ihalainen, Leena Pohjala, Henrik Ehlers, Ivan Kassamakov, Edward Haeggström, Pia Vuorela, Jouko Peltonen, Niklas Sandler

    Organizations: Pharmaceutical Sciences Laboratory, Department of Biosciences, Abo Akademi University, Tykistökatu 6A, FI-20520 Turku, Finland, Center of Excellence for Functional Materials, Laboratory of Physical Chemistry, Abo Akademi University, Porthaninkatu 3-5, FI-20500 Turku, Finland, Electronics Research Laboratory, Department of Physics, Division of Materials Physics, University of Helsinki, P.O. Box 64, FI-00014 Helsinki, Finland

    We combined conventional inkjet printing technology with flexographic printing to fabricate drug delivery systems with accurate doses and tailored drug release. Riboflavin sodium phosphate (RSP) and propranolol hydrochloride (PH) were used as water-soluble model drugs. Three different paper substrates: A (uncoated woodfree paper), B (triple-coated inkjet paper) and C (double-coated sheet fed offset paper) were used as porous model carriers for drug delivery. Active pharmaceutical ingredient (API) containing solutions were printed onto 1 cm × 1 cm substrate areas using an inkjet printer. The printed APIs were coated with water insoluble polymeric films of different thickness using flexographic printing. All substrates were characterized with respect to wettability, surface roughness, air permeability, and cell toxicity. In addition, content uniformity and release profiles of the produced solid dosage forms before and after coating were studied. The substrates were nontoxic for the human cell line assayed. Substrate B was smoothest and least porous. The properties of substrates B and C were similar, whereas those of substrate A differed significantly from those of B, C. The release kinetics of both printed APIs was slowest from substrate B before and after coating with the water insoluble polymer film, following by substrate C, whereas substrate A showed the fastest release. The release rate decreased with increasing polymer coating film thickness. The printed solid dosage forms showed excellent content uniformity. So, combining the two printing technologies allowed fabricating controlled-release oral dosage forms that are challenging to produce using a single technique. The approach opens up new perspectives in the manufacture of flexible doses and tailored drug-delivery systems.