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    The change in thickness of the solidified liquid layer rather than the immobilized mass determines the frequency response of a quartz crystal microbalance

    Year: 2012

    Journal: SCIENCE CHINA Chemistry, Volume 55, Number 1 (2012), 175-181, 20120618

    Authors: JianAn He(1), YuDong Lu(2), Jing Fang(1,3), HongWei Ma(2,3)

    Last authors: HongWei Ma

    Organizations: 1.Department of Biomedical Engineering, College of Engineering, Peking University, Beijing, 100871 China 2.Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, 215123 China 3.Biomed-X Research Center, Academy of Advanced Interdisciplinary Studies, Peking University, Beijing, 100871 China

    Country: China

    The “solidified liquid layer” model has been examined using a quartz crystal microbalance (QCM) with a polymeric matrix. The model is shown to give a reasonable explanation for the following experimental observations: (i) The opposite response of the QCM and surface plasmon resonance (SPR) for the activation process; (ii) the marked difference in the responses for IgG/anti-IgG interaction between QCM and SPR. Theoretical analysis and experimental results indicated that QCM is sensitive to the thickness change of the “solidified liquid layer” but not the mass of captured biomolecules (i.e., the immobilized mass), implying caution must be taken in interpreting QCM results.