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    The homopolymer poly (3-hydroxyoctanoate) as a matrix material for soft tissue engineering

    Year: 2011

    Journal: Journal of applied polymer science 2011, 122 (6) pp 3606-3617, 20121211

    Authors: Ranjana Rai, Aldo R. Boccaccini, Jonathan C. Knowles, Nicola Mordon, Vehid Salih, Ian C. Locke, M. Moshrefi-Torbati, Tajalli Keshavarz, Ipsita Roy

    Organizations: Department of Molecular and Applied Bio Sciences, School of Life Sciences, University of Westminster, London W1W 6UW, United Kingdom, Department of Materials, Imperial College London, London SW7 2AZ, United Kingdom, Department of Materials Science and Engineering, University of Erlangen, Nuremberg Cauerstraße 6, 91058 Erlangen, Germany, Division of Biomterials and Tissue Engineering, University College London (UCL) Eastman Dental Institute, London WCIX 8LD, United Kingdom, World Class University (WCU) Research Centre of Nanobiomedical Science, Dankook University, San#29, Anseo-Dong, Dongnam-Gu, Cheonan-Si, Chungnam, 330–714, South Korea, Department of Biomedical Sciences, School of Life Sciences, University of Westminster, London W1W 6UW, United Kingdom, School of Engineering Sciences, University of Southampton, Southampton SO171BJ, United Kingdom

    The homopolymer poly(3-hydroxyoctanoate), produced from Pseudomonas mendocina with octanoate as a carbon feed, was studied as a potential biomaterial for soft tissue engineering, that is, as a cardiac patch and as matrices for skin tissue engineering. The polymer was fabricated into neat solvent-cast films of 5 and 10 wt %. Microstructural studies revealed the films as having a smooth surface topography with a root mean square value of 0.238 µm. The films also possessed moderate hydrophilicity when compared to other monomers of the polyhydroxyalkanoate family. Stress–strain curves of the films obtained was typical of that of elastomeric polymers. This elastomeric and flexible nature of the films makes them promising candidates for the proposed applications. Biocompatibility studies with the human adult low calcium temperature keratinocytes (HaCaT) keratinocyte cell line showed that the films were able to support the attachment, differentiation, and maturation of the HaCaT cells. In vitro degradation studies over a period of 4 months showed that the water absorption and weight loss increased progressively with time for the films. The films underwent hydrolytic degradation initiated on the surface and also showed an aging effect.