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    The influence of Ag+, Zn2+ and Cu2+ exhanged zeolite on antimicrobialand long term in vitro stability of medical grade polyether polyurethane

    Year: 2011

    Journal: Express polymer letters 2011, 5 pp 1028-1040, 20121211

    Authors: P. Kaali, M. M. Pérez-Madrigal, E. Strömberg, R. E. Aune, Gy. Czél, S. Karlsson

    Organizations: Department of Fibre and Polymer Technology, School of Chemical Science and Engineering, Royal Institute ofTechnology (KTH), SE-100 44 Stockholm, Sweden, Department of Polymer Engineering, University of Miskolc, HU-3515 Miskolc, Hungary, Department of Chemical Engineering, Technical University of Catalonia, Av. Diagonal 647, E-08028, Barcelona, Spain, Department of Material Science and Engineering, School of Industrial Engineering and Management, Royal Institute ofTechnology (KTH), SE-100 44 Stockholm, Sweden, Department of Material Science and Engineering, Norwegian University of Science and Technology (NTNU), NO-7491Trondheim, Norway, Presently, Vice-Chancellor of Skövde University, SE-541 28 Skövde, Sweden

    This study aims to investigate the limitations and applicability of different ion exchanged zeolites as antimicrobialadditive in thermoplastic polyether type polyurethanes. These composites were designed to improve the health qualityof hospitalized patients by expressing both biocompatibility and relevant antimicrobial activity. The zeolites wereexchanged with silver, copper and zinc ions and single, binary and ternary ion-exchanged zeolite-polyurethane compositeswere prepared. The antimicrobial activity and the resistance of the composites against the human environment play vitalrole in the applicability of the materials as a medical device therefore these properties were investigated. The antimicrobialtest were performed on Methicillin-resistant Staphylococcus aureus, Pseudomonas aeruginosa and Candida tropicalis. Thetests showed that the efficiency of the silver ions is superior to the other single ionic systems. Besides, the binary and ternaryion-exchanged samples had similar antimicrobial efficiency regardless the type of the ions in the zeolite.The biocompatibility tests were carried out in-vitro in artificial body fluids for a period of 12 weeks. As a result of the invitrotest, degradation of the composites were observed and the structural changes of the materials were detected anddescribed by Scanning Electron Microscopy, Contact Angle measurements and Attenuated Total Reflection Fourier TransformInfrared Spectroscopy.