Contact
    Start Publications The role of surface wettability and surface charge of ...
    ←  Publication Finder
    Attension

    The role of surface wettability and surface charge of electrosprayed nanoapatites on the behaviour of osteoblasts

    Year: 2010

    Journal: Acta Biomaterialia, Volume 6, Issue 3, March 2010, Pages 750-755, 20111221

    Authors: E.S. Thian a,b, * , Z. Ahmad c , J. Huang c , M.J. Edirisinghe c , S.N. Jayasinghe c , D.C. Ireland d , R.A. Brooks d , N. Rushton d , W. Bon?eld b , S.M. Best b

    Organizations: a Department of Mechanical Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117 576, Singapore, b Department of Materials Science and Metallurgy, University of Cambridge, Pembroke Street, Cambridge CB2 3QZ, UK, c Department of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE, UK, d Orthopaedic Research Unit, University of Cambridge, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 2QQ, UK

    A new deposition method is presented, based on electrospraying, that can build bioceramic structures with desirable surface properties. This technology allows nanoapatite crystals, including hydroxyapatite (nHA), carbonate-substituted HA (nCHA) and silicon-substituted HA (nSiHA), to be electrosprayed on glass substrates. Human osteoblast cells cultured on nSiHA showed enhanced cell attachment, proliferation and protein expression, namely alkaline phosphatase, type 1 collagen and osteocalcin, as compared to nHA and nCHA. The modification of nanoapatite by the addition of silicon into the HA lattice structure renders the electrosprayed surface more hydrophilic and electronegatively charged.