Contact
    Start Publications Thermodynamic studies of bovine lung surfactant extract mixing ...
    ←  Publication Finder
    Attension

    Thermodynamic studies of bovine lung surfactant extract mixing with cholesterol and its palmitate derivative

    Year: 2007

    Journal: Journal of Colloid and Interface Science, Volume 311, Issue 2, 15 July 2007, Pages 551-555, 20111221

    Authors: A.K. Pandaa, K. Nagb, R.R. Harbottleb, F. Possmayerc and N.O. Petersen

    Organizations: Department of Chemistry, Behala College, Kolkata 700 060, West-Bengal, India, Department of Chemistry, The University of Western Ontario, London, ON N6A 5B7, Canada, Department of Obstetrics and Gynecology, The University of Western Ontario, London, ON N6A 5C1, Canada

    Langmuir film behavior of bovine lipid extract surfactant (BLES), mixed with cholesterol (CHOL) and cholesterol palmitate (CHOLP), has been studied by surface pressure (π)–area (A) measurements. Associative interactions, observed for both systems, were less favored at lower BLES content. The presence of unsaturated phospholipids and surfactant proteins in BLES favored the association. Miscibility of BLES was better with CHOLP than with CHOL at all compositions, indicating more compact packing of the BLES–CHOLP than of the BLES–CHOL system. The most stable mixtures were found at 30–40 mol% CHOL and at low π and at 20–25 mol% CHOLP but at higher π. These results suggest that BLES–CHOL miscibility is better at low π and low CHOL concentrations, while BLES–CHOLP miscibility is better at high π and high CHOLP concentrations.