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    Thiolated polyethylene oxide as a non-fouling element for nano-patterned bio-devices

    Year: 2007

    Journal: APPLIED SURFACE SCIENCE 253 (10): 4796-4804 MAR 15 2007, 20100827

    Authors: Lisboa P, Valsesia A, Colpo P, Gilliland D, Ceccone G, Papadopoulou-Bouraoui A, Rauscher H, Reniero F, Guillou C, Rossi F

    Last authors: Rossi F

    Organizations: European Commiss, Joint Res Ctr, Inst Hlth & Consumer Protect, I-21020 Ispra, Italy

    Country: Italy

    This work describes the synthesis of a thiolated polyethylene oxide that self-assembles on gold to create a non-fouling surface. Thiolated polyethylene oxide was synthesised by reacting 16-mercaptohexadecanoic acid with polyethylene glycol mono methyl ether. The coverage of the thiolated polyethylene oxide on gold was studied by cyclic voltammetry, and the modified surfaces were characterised by X-ray photoelectron spectroscopy and ellipsometry. Protein resistance was assessed using quartz crystal microbalance. Results showed a non-fouling character produced by the thiolated polyethylene oxide. The synthesised product was used as the passivation layer on nano-patterned surfaces consisting of arrayed nano-spots, fabricated by plasma based colloidal lithography. The specific adsorption of anti-bovine serum albumin in the mercaptohexadecanoic acid spots was verified by atomic force microscopy.