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    Ti surface modification with a natural antioxidant and antimicrobial agent

    Year: 2015

    Journal: SURFACE & COATINGS TECHNOLOGY, Vol. 276, p 175-185, 20170208

    Authors: Dumitriu, Cristina; Ungureanu, Camelia; Popescu, Simona; Tofan, Vlad; Popescu, Marian; Pirvu, Cristian

    Organizations: Univ Politehn Bucuresti, Bucharest 060042, Romania; Natl Inst Res & Dev Microtechnol, Bucharest 077190, Romania; Cantacuzino Natl Inst Res Dev Microbiol & Immunol, Bucharest 050096, Romania

    Ti surface was modified with a natural antioxidant and antimicrobial agent, torularhodin, by its incorporation onto a Ti/TiO2 substrate via anodization process. This natural antioxidant and antimicrobial agent can be produced from waste materials, as an alternative to synthetic antimicrobial compounds. Scanning electron microscopy (SEM), Structural Fourier Transform Infrared (FTIR) spectroscopy, contact angle (CA) measurements, and atomic force microscopy (AFM) are employed to assess the surface properties of resulting coatings. Surface and electrochemical analyses highlighted that torularhodin was embedded in the TiO2 shielding layer, improving the antibacterial activity with about 65% compared to Ti/TiO2. Several species of microorganisms: Staphylococcus aureus, Candida albicans and Aspergillus fumigatus were utilized to test the antimicrobial effect Hemolysis and cytotoxicity tests were additionally performed, showing good results. This nanostructured Ti surface based on a natural antioxidant and antibacterial agent is a promising biomaterial for medical device purposes. (C) 2015 Published by Elsevier B.V.