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    Two-Dimensional Order in ß-Sheet Peptide Monolayers

    Year: 2000

    Journal: J. Am. Chem. Soc. 2000, 122, 12523-12529, 20111221

    Authors: Hanna Rapaport, Kristian Kjaer, Torben R. Jensen, Leslie Leiserowitz, and David A. Tirrell

    Organizations: Contribution from the Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, Condensed Matter Physics and Chemistry Department, Ris National Laboratory, DK-4000 Roskilde, Denmark, and Department of Materials and Interfaces, Weizmann Institute of Science, Rehovot 76100, Israel

    Amphiphilic peptides comprising alternating hydrophilic and hydrophobic amino acid residues were designed to form super-secondary structures composed of self-assembled β-strands as monolayers at the airwater interface. Insights provided by in situ grazing-incidence X-ray diffraction (GIXD), surface pressure vs area isotherms, and Fourier transform infrared spectroscopy allow structural characterization of the assembled nanostructures and rational correlation with the peptide sequence. Peptides seven to seventeen amino acids in length were found to form crystalline arrays with coherence lengths in the range of 100 to 1000 Å. Twodimensional registry of the self-assembled peptides was induced by placement of proline residues at the peptide termini. The films were found to intercalate ordered arrays of ions between juxtaposed β-sheet ribbons to generate peptide-ion composite phases.