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Two-dimensional supramolecular assemblies involving neoglycoplipids: Self-organization and insertion properties into Langmuir monolayers

Year: 2011

Journal: Biochimie, 2011, 93 (1), 101-112, 20131009

Authors: Yves Queneau, Fabienne Dumoulin, Rouba Cheaib, Stéphane Chambert, Chantal Andraud, Yann Bretonnière, Loïc J. Blum, e, Paul Boullanger, Agnès Girard-Egrot

Organizations: Institut de Chimie et de Biochimie Moléculaires et Supramoléculaires, UMR 5246, CNRS, université de Lyon, université Lyon 1, INSA-Lyon, CPE-Lyon, Bât. Curien, 43 Bd du 11 Novembre 1918, F 69622 Villeurbanne, France; ICBMS, Laboratoire de Chimie Organique et Bioorganique, INSA Lyon, Bât. J. Verne, 20 Avenue A. Einstein, 69621 Villeurbanne Cedex, France; ICBMS, Laboratoire de Chimie Organique 2 – Glycochimie, France; Université de Lyon, Laboratoire de Chimie de l’ENS Lyon, UMR 5182 CNRS-ENS Lyon, 46 allée d’Italie, 69364, Lyon, France; ICBMS, Laboratoire de Génie Enzymatique, Membranes Biomimétiques et Assemblages Supramoléculaires, France

In nature, interfacial molecular recognition and chirality are of fundamental significance for the construction of biological assemblies. Lipid monolayers at liquid interface can be used as biomimetic models for studying molecular interactions in such assemblies. In this article, we will focus on the use of Langmuir monolayers for studying self-organization and insertion properties of several neoglycolipids. Two types of glycolipids have been considered, one in the context of the analysis of glycoconjugates of biological relevance, and one dealing with the ability of some glycoprobes to insert into a monolayer in relation with their efficiency for serving as membrane imaging systems.